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  • Title: [Erythropoiesis in the mouse following chronic administration of small doses of busulphan (author's transl)].
    Author: Buys MC, Carrera MA, Guidi EE, Miranda CE, Alvarez AR, Scaro JL.
    Journal: Rev Esp Fisiol; 1977 Sep; 33(3):163-7. PubMed ID: 897319.
    Abstract:
    After both splenectomized and non-splenectomized mice had received a total amount of five doses of Busulfan at a rate of 0.14 mg/48 h, the recovery of their erythropoietic organs through the addition of 59Fe was investigated, after the cytostatic treatment had been cut off. In the non-splenectomized animals recovery was clear, keeping high 59Fe uptake values, significantly above normal, throughout the 21 days of the experiment. In the splenectomized mice, 59Fe uptake reached a peak of 38 per cent three days after the supply had been cut off, and from then on it descended to subnormal values.
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