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  • Title: DMSO induces apoptosis in SV40-transformed human keratinocytes, but not in normal keratinocytes.
    Author: Koike M, Ishino K, Kohno Y, Tachikawa T, Kartasova T, Kuroki T, Huh N.
    Journal: Cancer Lett; 1996 Nov 29; 108(2):185-93. PubMed ID: 8973593.
    Abstract:
    We found that dimethyl-sulfoxide (DMSO) at concentrations of 2.5% induced apoptosis in SV40-immortalized human keratinocytes, while normal keratinocytes were arrested at the boundary of G1/S phase under the same conditions. DMSO-induced apoptosis in SV-40 immortalized keratinocytes was not associated with change in phosphorylated state of the retinoblastoma susceptibility gene. When SV40-immortalized cells were treated with 2.5% DMSO, dissociation of the complex was observed by immunoblotting of SV40 T antigen from immunoprecipitated p53 protein fraction.
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