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  • Title: [Intra-arterial thrombolysis in peripheral bypass and arterial occlusions. Results and predictive factors for thrombolysis].
    Author: Sandbaek G, Staxrud LE, Rosén L, Bay D, Stiris M, Gjølberg T.
    Journal: Tidsskr Nor Laegeforen; 1996 Oct 20; 116(25):3000-4. PubMed ID: 8975423.
    Abstract:
    The purpose of the study was to reveal the association between successful intra-arterial thrombolysis in peripheral arterial and graft occlusions and the following factors: sex, age, symptoms, duration of symptoms, length of occlusion, conduit type, runoff and catheter localisation. Forty-six patients were treated with continuous intra-arterial infusion of streptokinase. Twelve patients were given tissue plaminogen activator (tPA). In the streptokinase-group successful lysis was achieved in 27 of 46 patients (59%). A significant association was found between successful thrombolysis and good runoff (p < 0.01). Catheter position above the occlusion resulted in lysis in only 1 of 11 patients. Lysis was achieved in nine of 12 patients (75%) treated with tPA. In this study, good runoff and intrathrombotic infusion were almost prerequisites for obtaining a positive immediate outcome. Other factors were less important.
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