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  • Title: [A new type of ionotropic glutamate receptors].
    Author: Solov'ev MM, Barnard EA, Grishin EV.
    Journal: Bioorg Khim; 1996 Jun; 22(6):468-71. PubMed ID: 8975675.
    Abstract:
    The possibility of the existence of a new type of ionotropic glutamate receptor differing from NMDA and non-NMDA receptors was confirmed by cloning cDNA for XenNR1, a channel-forming subunit of the glutamate receptor from the Xenopus laevis brain. Cotransfection of the HEK-293 cells with the cDNAs for XenNR1 and XenU1 (a non-NMDA receptor subunit from X. laevis brain) resulted in the biosynthesis of a functionally active heterosubunit receptor composed of NMDA and non-NMDA subunits. The functional co-expression of the XenNR1 and XenU1 cDNAs is the first direct evidence for the existence of a new type of glutamate receptor.
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