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  • Title: Molecular evidence for pap-G specific adhesion of Escherichia coli to human renal cells.
    Author: Söderhäll M, Bergerheim US, Jacobson SH, Lundahl J, Möllby R, Normark S, Winberg J.
    Journal: J Urol; 1997 Jan; 157(1):346-50. PubMed ID: 8976295.
    Abstract:
    PURPOSE: To study the interaction between class II G-adhesin of Escherichia coli and human urogenital cells. MATERIAL AND METHODS: The adherence of two wild type P-fimbriated E. coli strains, both carrying a class II G-adhesion, and two constructed mutants (one class II G-adhesion knock-out mutant and one class switch mutant in which the papG gene was exchanged with a prsJ96 allele which is a representative of the class III G-adhesin) to human urogenital cells were examined by light microscopy and flow cytometry. RESULTS: The wild type E. coli strains adhered avidly to proximal tubular cells, but the isogenic mutant strains did only adhere in one of the experiments. A soluble receptor analogue inhibited bacterial attachment. CONCLUSIONS: These experiments strongly suggest that the papG class II tip adhesin of P-fimbriae is essential in the pathogenesis of human kidney infection.
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