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  • Title: Pooled human immunoglobulins contain anti-idiotypes with reactivity against the SLE-associated 4B4 cross-reactive idiotype.
    Author: DeKeyser F, DeKeyser H, Kazatchkine MD, Rossi F, Dang H, Talal N.
    Journal: Clin Exp Rheumatol; 1996; 14(6):587-91. PubMed ID: 8978951.
    Abstract:
    OBJECTIVE: To identify anti-idiotype antibody activity against a regulatory anti-Sm idiotype (4B4) in pooled human IgG (IVIG). METHODS: ELISA were used to determine anti-idiotype antibody activity in IVIG. RESULTS: Anti-idiotype antibody activity to 4B4 was detected in IVIG. The anti-idiotypic activity in IVIG could be inhibited by antigen, Sm, and rabbit anti-idiotypic antiserum. The idiotypic binding activity was predominately directed against the 4B4 VH region. CONCLUSION: IVIG contains antibodies against a lupus-associated crossreactive idiotype. These antibodies represent Ab2 beta type antibodies. The anti-idiotypic activity in IVIG may be relevant to the efficacious use of IVIG in treating rheumatic diseases.
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