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  • Title: DNA-ploidy studies on cytological preparations from breast cancers by image analysis: comparison with Feulgen staining performed in destained Papanicolaou slides.
    Author: Sidoni A, Cavaliere A, Alunno P, Bucciarelli E.
    Journal: Cytometry; 1996 Dec 15; 26(4):293-7. PubMed ID: 8979029.
    Abstract:
    Image cytometric analysis of DNA ploidy status of 40 fresh primary breast carcinomas was performed in a comparative study on cytologic preparations stained directly by the Feulgen method and smears from the same tumors Feulgen-stained after Papanicolaou staining. There was a 0.82 overall concordance in diploid and aneuploid tumor classification and a good correlation (r = 0.736, P < 0.001) between the DNA indices determined by the two methods. Discordances are probably due to tumor heterogeneity. This study demonstrates that image cytometric DNA analysis on previously routine-stained cytologic preparations is feasible and reliable for pretreatment DNA analysis and suggests potential applications in retrospective studies with cytologic material from archives.
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