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  • Title: Role of glucose-6-phosphate in cerebral dysfunction following hypoxia and hypotension.
    Author: Proctor HJ, Wood JJ.
    Journal: Surg Neurol; 1977 Sep; 8(3):225-6. PubMed ID: 897997.
    Abstract:
    Rats were "stressed" by a 30-minute period of breathing 7.5% oxygen combined with hemorrhagic hypotension (x arterial pressure = 25 mm Hg), and then "resuscitated" by restoring the inspired oxygen concentration to 30% and reinfusing the blood previously removed to produce hypotension. We have previously noted in initial return of brain adenosine-triphosphate to normal after this "stress" followed by a progressive decline during the post-resuscitation period. In this study, substrate deficiency was investigated as a possible etiology for the decreased adenosine-triphosphate. Glucose and glucose-6-phosphate concentrations in the brain were measured before "stress" and after resuscitation and were found not to change, indicating no deficiency of substrate.
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