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  • Title: A complex of the soluble interleukin-6 receptor and interleukin-6 is internalized via the signal transducer gp130.
    Author: Graeve L, Korolenko TA, Hemmann U, Weiergräber O, Dittrich E, Heinrich PC.
    Journal: FEBS Lett; 1996 Dec 09; 399(1-2):131-4. PubMed ID: 8980136.
    Abstract:
    In human body fluids a soluble form of the interleukin-6 receptor (sIL-6R) has been found which together with interleukin-6 (IL-6) acts agonistically on cells expressing the signal transducer gp130. The means by which the sIL-6R is removed from the circulation is unknown. Here, we show that a complex of 125I-labelled recombinant sIL-6R and IL-6 is internalized by MDCK cells stably transfected with gp130 and by human hepatoma cells HepG2 that endogenously express the IL-6R and gp130. We further show that most of the internalized sIL-6R is degraded within lysosomes. Our studies suggest that cells expressing gp130 are capable of endocytosing an IL-6/sIL-6R complex, thereby removing both from the circulation.
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