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  • Title: Pharmacological activity of the new calcium antagonist, lacidipine, on isolated preparations.
    Author: Raddino R, Metra M, Nodari S, Pelá G, Fappani A, Dei Cas L.
    Journal: Gen Pharmacol; 1996 Oct; 27(7):1255-9. PubMed ID: 8981077.
    Abstract:
    1. The calcium-channel blocking activity of lacidipine has been studied compared with that of nifedipine and verapamil on the isolated rabbit heart and aorta. 2. All the compounds induced a dose-dependent negative inotropic effect (10(-8)-10(-5) M); although lacidipine showed less, but longer lasting, activity. 3. Lacidipine showed a weak negative chronotropic effect and nifedipine was ineffective. Only verapamil strongly decreased the heart rate. 4. The three calcium antagonists abolished vasopressin-induced coronary spasm and inhibited partially metoxamine-induced coronary spasm. Only lacidipine reduced basal coronary pressure. 5. In the aortic strips, all the compounds antagonized KCl-induced contractions, and they exerted a partial effect on noradrenaline- and angiotensin II-induced contractions.
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