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  • Title: Acute psychosis associated with abrupt withdrawal of carbamazepine following intoxication.
    Author: Darbar D, Connachie AM, Jones AM, Newton RW.
    Journal: Br J Clin Pract; 1996 Sep; 50(6):350-1. PubMed ID: 8983329.
    Abstract:
    Carbamazepine is regularly used in the treatment of trigeminal neuralgia. Although exacerbation of psychosis has been described following abrupt discontinuation of carbamazepine in chronic schizophrenics, a withdrawal syndrome has not been reported previously in patients treated for trigeminal neuralgia. The case presented here suggests that abrupt withdrawal of toxic concentrations of carbamazepine may precipitate a withdrawal reaction, which is manifest some days after discontinuation of the drug. Therefore it may be advisable to withdraw therapy slowly in these situations.
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