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  • Title: [High-dose carboplatin superselective intraarterial chemotherapy in advanced head and neck cancer].
    Author: Benazzo M, Bernardo G, Corbella F, Danova M, Lanza L, Zappoli F, Uggetti C, Mira E.
    Journal: Acta Otorhinolaryngol Ital; 1996 Feb; 16(1):30-4. PubMed ID: 8984837.
    Abstract:
    Advances in vascular radiology techniques for superselective transfemoral arterial infusion prompted us to evaluate the effects of high-dose rapid regional carboplatin infusion for patients with advanced head and neck squamous cell carcinomas. Twenty untreated patients received three infusions of carboplatin (300-350 mg/m2) every 2 weeks with this method. All the infusions were performed without any complication. Treatment was well tolerated, with moderate (Grade 1-3 WHO) local toxicity (stomatitis, dermatitis and alopecia) and minimal (Grade 1-2 WHO) myelosuppression. The total response index (complete response plus partial response) was 94% for primary tumors and 50% for neck metastases. Neoadjuvant chemotherapy employing superselective rapid infusion of high-dose carboplatin is a feasible, relatively nontoxic, effective technique and may have important applications in multimodality therapy of untreated patients with advanced head and neck cancer.
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