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  • Title: Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS.
    Author: Yoshikai Y, Kidokoro H, Kimura K, Aoki Y, Makino M, Hiromatsu K.
    Journal: J Virol; 1997 Jan; 71(1):746-9. PubMed ID: 8985410.
    Abstract:
    Subcutaneous injection of FK506 (10 mg/kg of body weight) completely blocked the clonal expansion of staphylococcal enterotoxin A (SEA)-reactive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mice are characterized by utilization of a FK506-insensitive pathway for clonal expansion of superantigen-reactive T cells.
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