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  • Title: Synthesis of novel thiazolo[4,5-d]pyrimidine derivatives for antimicrobial, anti-HIV and anticancer investigation.
    Author: Rida SM, Habib NS, Badawey EA, Fahmy HT, Ghozlan HA.
    Journal: Pharmazie; 1996 Dec; 51(12):927-31. PubMed ID: 8985982.
    Abstract:
    Some novel thiazolo[4,5-d]pyrimidines containing 6-arylideneamino (3a-e). 2-dicyanomethylidene (5a), 2-(cyanoethoxy carbonyl) methylidene (5b) or 2-hydrazono (7a, b) moieties were synthesized. The prepared compounds were tested in vitro for their antibacterial, antifungal, anti-HIV and anticancer activities. Most of them showed promising antifungal activity, but only a few compounds exhibited anticancer activity.
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