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  • Title: Central nervous system involvement at diagnosis in a case of pediatric CD30+ anaplastic large cell lymphoma.
    Author: Kaplinsky C, Toren A, Neumann Y, Mandel M, Kenet G, Sharon N, Rechavi G, Biniaminov M, Rubanov V, Rosenthal E, Rosner E, Mark Z, Amariglio N, Brok-Simoni F.
    Journal: Med Pediatr Oncol; 1997 Feb; 28(2):132-5. PubMed ID: 8986149.
    Abstract:
    Central nervous system (CNS) involvement in Ki-1/CD30 lymphoma is extremely rare, in contrast to the frequent involvement in other types of pediatric non-Hodgkin's lymphoma. No mechanism has yet been proposed to explain the sparing of the blood brain barrier in Ki-1/lymphoma. We present a 2-year-old boy who was admitted to the Department of Pediatric Hemato-Oncology due to lethargy, progressive breathing difficulties, massive diffuse lymphadenopathy, hepatosplenomegaly, and ichthyosis-like skin involvement with epidermolysis. A lymph node biopsy was compatible with Ki-1/CD30 anaplastic large cell lymphoma (ALCL). Bone marrow aspirate and biopsy demonstrated reactive hyperplasia. Cytogenetic analysis displayed hyperdiploid cells with 1p(-) in most cells. Cerebrospinal fluid examination showed pleocytosis with CD30+ cells. Possible mechanisms which could enable CNS involvement in this unusual case are discussed.
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