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  • Title: Three-part inventions: intracellular signaling and induced proximity.
    Author: Crabtree GR, Schreiber SL.
    Journal: Trends Biochem Sci; 1996 Nov; 21(11):418-22. PubMed ID: 8987395.
    Abstract:
    Everyone has had the experience of stoking a fire; putting the logs close together causes flames to appear from previously dying embers. In a similar way, mere proximity might mediate qualitative biological responses. We discuss natural molecules that appear to have arisen to bring two proteins together and illustrate how this simple mechanism can be used to control a wide variety of biological processes.
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