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  • Title: [Increased urinary iron excretion rate in patients with non-insulin dependent diabetes mellitus].
    Author: Nishiya K, Takamatsu K, Yoshimoto Y, Ikeda Y, Ito H, Hashimoto K.
    Journal: Rinsho Byori; 1996 Dec; 44(12):1201-2. PubMed ID: 8990941.
    Abstract:
    Urinary iron excretion rate(u-FeER, microgram/min) in urine at night time from 58 patients with non-insulin dependent diabetes mellitus and 8 controls was measured by atomic absorption. The patients were divided into three groups according to urinary albumin excretion rate(u-AER), namely, Group I(n = 44): less than 20 micrograms/min of u-AER; Group II(n = 9): 20 < or = u-AER < 200 micrograms/min; Group III(n = 5): more than 200 micrograms/min of u-AER. The u-FeER in group III(56.3 +/- 14.8 ng/min, mean +/- SEM) was significantly higher than that in controls (4.0 +/- 1.6ng/min), group I(8.3 +/- 1.6 ng/min) and group II(18.5 +/- 6.5ng/min). The increase of u-FeER in group III indicates that urinary iron may at least partly play a role in development of diabetic nephropathy.
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