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  • Title: [Marchiafava-Bignami disease: development with flare-up].
    Author: Moreaud O, Dufossé N, Pellat J.
    Journal: Rev Neurol (Paris); 1996; 152(8-9):560-2. PubMed ID: 8991181.
    Abstract:
    Marchiafava-Bignami disease is a complication of chronic ethanol intoxication. The clinical course may be acute, rapidly leading to death, or marked by a progressive dementia. A form with favorable outcome is also described. During the evolution of chronic forms, acute worsenings are possible, with subsequent partial recovery. We report a clinico-radiological case, where a first episode was followed by a good outcome. After a second episode, 3 years later, the patient developed a dementia with predominant frontal lobe signs. This case suggests that, even after a favorable outcome, a long-term poor prognosis cannot be ruled out.
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