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  • Title: [Mechanism of action of aspartic proteinases. 2. Conformational possibilities of an HIV-1 proteinase substrate].
    Author: Popov ME, Kashparov IV, Popov EM.
    Journal: Bioorg Khim; 1996 Jul; 22(7):510-22. PubMed ID: 8992956.
    Abstract:
    Theoretical conformational analysis of a hexapeptide fragment p17-p24 of the native substrate of the HIV-1 protease was reported. The geometrical and energy parameters of all possible optimal conformations were determined. The data which are necessary for the calculation of the mechanism of the catalytic act of HIV-1 protease were obtained.
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