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  • Title: Short- and long-term regulation of tyrosine hydroxylase in chromaffin cells by VIP and PACAP.
    Author: Haycock JW.
    Journal: Ann N Y Acad Sci; 1996 Dec 26; 805():219-30; discussion 230-1. PubMed ID: 8993405.
    Abstract:
    Whereas cholinergic neurotransmitters are responsible for the release of a substantial portion of the CAs released from rat chromaffin cells by activation of the splanchinc nerves, the present data suggest that noncholinergic neurotransmission appears to play a more substantial role in the short- and long-term homeostatic regulation of TH activity, which serves to maintain the stores of CAs for subsequent release. In addition, studies using the PKA-deficient PC12 cells provided the first direct evidence that PKA actually mediates the phosphorylation of Ser40 in situ.
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