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  • Title: Ultrastructure of the uterine epithelium of mice treated neonatally with estrogen.
    Author: Mori T.
    Journal: Acta Anat (Basel); 1977; 99(4):462-8. PubMed ID: 899711.
    Abstract:
    In neonatally estrogenized mice, uterine epithelial cells possessed a few microvilli on the fuzzy-appearing apical surface, regardless of the presence or the absence of estrogen. The cells showed well-developed rough endoplasmic reticulum and a large number of mitochondria, suggesting that the cells were actively functioning. At 13 months of age, the uterine epithelium of neonatally estrogenized mice was sometimes stratified and squamous. Spherical basal cells like those appearing in cancerous vagina in estrogen-treated mice made their appearance. These cells may have the capacity of autonomous proliferation. 20 female C57 Black/Tw mice were given daily sc injections of estradiol-17beta (20 mcg) from birth to 10 days. All were ovariectomized at 2 months of age. 2 groups of 5 mice were sacrificed at 3 and 13 months, respectively, without further treatment. 2 groups of 5 were given a single injection of estradiol (10 mcg) at 3 and 13 months, respectively, and sacrificed 48 hours later. 4 additional groups treated neonatally with vehicle only served as controls. Sections from the middle part of each uterine horn were examined with a Hitachi HS-9 electron microscope. In neonatally estrogenized mice, uterine epithelial cells possessed a few microvilli on the fuzzy appearing apical surface, regardless of the presence or absence of estrogen. The cells showed well-developed rough endoplasmic reticulum and a large number of mitochondria, suggesting that the cells were actively functioning. At 13 months of age, the uterine epithelium of neonatally estrogenized mice was sometimes stratified and squamous. Spherical basal cells like those appearing in cancerous vaginas in estrogen-treated mice made their appearance. These cells may have the capacity of autonomous proliferation.
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