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  • Title: Effect of thymoanaleptic agents on the course of experimental arterial hypertension and catecholamine content in tissues and urine.
    Author: Bobkiewicz T, Chodera A, Godlewski J, Nowakowska E.
    Journal: Acta Physiol Pol; 1977; 28(3):195-201. PubMed ID: 899810.
    Abstract:
    Experimental hypertension was induced in rats by two methods. In the course of hypertension development the rats of experimental groups were treated with following tricyclic antidepressive agents: Imipramine, Opipramol, Amitriptylline and Nortriptylline injected in doses of 5.0 or 0.5 mg per 1 kg of body weight. Higher doses of the above drugs inhibited the development of hypertension, whereas the lower doses had no effect on arterial blood pressure.
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