These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
Pubmed for Handhelds
PUBMED FOR HANDHELDS
Search MEDLINE/PubMed
Title: [Anticholinergic action of clonidine on cardiovascular effects of the central cholinergic estimulation]. Author: Taira CA. Journal: Acta Physiol Pharmacol Ther Latinoam; 1996; 46(2):119-26. PubMed ID: 8998366. Abstract: A study was made relating the anticholinergic action of alpha 2-adrenoceptor agonist clonidine on the cardiovascular responses to i.c.v. injection of neostigmine, a quaternary anticholinesterase, in conscious rats. The cholinergic agent neostigmine (0.1-1 microgram i.c.v.) induced a dose-dependent pressor and bradycardic responses in the rats. Clonidine (10 micrograms.kg-1 i.v.), given 30 min previous the anticholinesterase, failed to modify the pressor effect of neostigmine (0.1-1 microgram i.c.v.) but prevented the bradycardia. On the other side, the i.c.v. administration of clonidine (3 micrograms), given 15 min before neostigmine, only prevented the bradycardic effect of neostigmine (0.3 microgram i.c.v.) but not the central pressor action of this drug. The results support the idea that clonidine has an anticholinergic action in the rat. However, prevention by clonidine of central cholinergic bradycardia suggests different cholinergic-adrenergic interaction on the cardiovascular responses elicited by central administration of cholinergic agents.[Abstract] [Full Text] [Related] [New Search]