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Title: Fatty acid composition of erythrocyte membranes affects iron absorption in rats. Author: Rodriguez MC, Sáiz MP, Muntané J, Mitjavila MT. Journal: J Nutr; 1996 Dec; 126(12):3109-17. PubMed ID: 9001381. Abstract: We studied the influence of the fatty acid composition of three different diets on iron absorption in relation to the lipid peroxidation of the erythrocyte membranes. After weaning, three groups of rats were fed isoenergetic semipurified diets for 16 wk: control diet (containing canola oil and peanut oil), tripalmitin diet (a saturated fatty acid diet) and a sardine oil diet rich in polyunsaturated fatty acids. Eight rats from each group were administered 59FeSO4 by gastric intubation for ferrokinetic studies, and six rats from each group were used for several analyses in blood, liver, spleen and erythrocytes. Results obtained from 59Fe eliminated in feces and 59Fe present in plasma, both calculated by the area under the curve and from maximum concentration in plasma, indicated that the sardine oil diet induced higher iron absorption than the control diet. The lipid peroxidation of erythrocyte membranes in rats fed sardine oil was higher than that in control rats due to high membrane's (n-3) polyunsaturated fatty acid content and low alpha-tocopherol level. The 59Fe in liver and spleen of rats fed the sardine oil diet was higher than in rats fed the control diet, and 59Fe was diverted to erythrocytes to a greater extent than in rats fed the control diet due to their reduced life-span. The sardine oil diet, by lessening alpha-tocopherol and raising the degree of lipid peroxidation in erythrocytes, augments iron absorption, whereas the tripalmitin diet, by protecting erythrocyte membranes from lipid peroxidation, leads to a lower rate of iron absorption.[Abstract] [Full Text] [Related] [New Search]