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  • Title: Improved determination of sulfadiazine in human plasma and urine by high-performance liquid chromatography.
    Author: Metz R, Muth P, Ferger M, Bolten WW, Vergin H.
    Journal: J Chromatogr A; 1996 Apr 05; 729(1-2):243-9. PubMed ID: 9004946.
    Abstract:
    A high-performance liquid chromatographic method for the determination of sulfadiazine in human plasma and human urine was developed and validated. The method involves the acid extraction of drug and internal standard from plasma with ethyl acetate followed by evaporation and reconstitution in mobile phase. Urine samples were simply diluted with purified water. Recovery, linearity, intra- and inter-day variation of sulfadiazine were tested and found appropriate. The quantitation range was 0.0299-15.2 micrograms/ml for plasma samples and 0.578-148.8 micrograms/ml for urine samples. The method is suitable for the quantitation of sulfadiazine from pharmacokinetic studies.
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