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  • Title: [The dynamic biosynthesis of nicotinamide coenzymes from nicotinamide and nicotinic acid in rat tissues].
    Author: Fedyk MIa, Velykyĭ MM, Zababurina ML, Oliiarnyk OD.
    Journal: Ukr Biokhim Zh (1978); 1996; 68(2):29-33. PubMed ID: 9005656.
    Abstract:
    Dynamics of nicotinamide coenzyme biosynthesis in rat tissues has been studied systematically with previous injection of two main precursors nicotinic acid and nicotinamide (50 mg/100 g of weight. This process is characterized by exact tissue specificity. As a precursor of NAD-biosynthesis nicotinamide was used more intensively in the liver and brain tissues. In the mucous tissue of intestine nicotinic acid was utilized more intensively. An increase in the NADP+ content in tissues with high level of NAD+ biosynthesis is limited as a result of competition between these two processes for the intracellular ATP level.
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