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  • Title: [Clinical trials of ofloxacin in sequential use (intravenous and oral) in patients with serious hospital infection].
    Author: Iakovlev SV, Dvoretskiĭ LI, Shakhova TV, Kudinkina IP, Vorob'ev PA, Vlasenko NA, Prokhorenko TS, Eremina LV.
    Journal: Antibiot Khimioter; 1996; 41(9):53-6. PubMed ID: 9005788.
    Abstract:
    Fifteen patients with severe hospital infections such as postoperative pneumonia or intraabdominal sepsis were treated with ofloxacin in a dose of 400 mg once a day for 7 to 14 days (11 days at the average). The drug was administered intravenously for the first 3-5 days and then orally till the end of the treatment course. The clinical effect was observed in 14 patients (93 per cent) and the positive bacteriological effect was stated in 11 out of 13 patients (85 per cent). Before the treatment 18 microbial cultures were isolated from the patients. 94 per cent of them was susceptible to ofloxacin. The isolates of Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa were the most frequent. The treatment resulted in the eradication of 15 cultures (83 per cent). The adverse reactions were observed in 3 patients but only in 1 of them they were for certain due to the drug use. All the adverse reactions were insignificant or moderate and did not require the treatment discontinuation. The trials showed that ofloxacin was a highly efficient agent useful in the empirical monotherapy of patients with severe hospital infection.
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