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  • Title: Cirrhotic glomerulonephritis: an underdiagnosed condition.
    Author: Ori Y, Korzets A, Sandbank J, Lurie B, Zeidman A, Gafter U.
    Journal: Isr J Med Sci; 1996 Dec; 32(12):1222-4. PubMed ID: 9007158.
    Abstract:
    Glomerular pathology in liver cirrhosis is common in autopsies but is underdiagnosed antemortem. The most common pathologic findings are mesangial disease with immunoglobulin A deposits, and membranoproliferative glomerulonephritis. The latter is associated, most frequently, with hepatitis C infection and cryoglobulinemia. We describe a patient with longstanding liver cirrhosis who presented with a nephritic and nephrotic syndrome. Membranoproliferative glomerulonephritis was diagnosed on kidney biopsy. There was no clinical, laboratory or histologic evidence of hepatitis C infection or cryoglobulinemia. The different aspects of "cirrhotic glomerulonephritis" are discussed and the need for searching for this underdiagnosed condition in patients with chronic liver disease is emphasized.
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