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  • Title: An estimate of the participation of the sarcoplasmic reticulum in the intracellular Ca2+ regulation in adult and newborn ferret hearts.
    Author: Bonnet V, Léoty C.
    Journal: Comp Biochem Physiol A Physiol; 1996 Dec; 115(4):341-8. PubMed ID: 9008357.
    Abstract:
    The aim of the present study was to estimate the participation of the sarcoplasmic reticulum in the Ca2+ regulation of the contraction of newborn ferret heart. Cyclopiazonic acid has been used to block the sarcoplasmic reticulum Ca2+ pump in adult and newborn (1 month and 5-6 day old) ferret ventricles of intact and saponin-treated preparations. Cyclopiazonic acid induced a decrease of the amplitude of the caffeine contractures generated in saponin skinned fibers. The sensitivity of the sarcoplasmic reticulum Ca2+ uptake to cyclopiazonic acid was similar in adult and newborn hearts. In intact preparations, cyclopiazonic acid (1-20 microM) induced a negative inotropic effect on the twitch with a prolongation in its kinetics. The maximal decrease in the amplitude of the twitch was larger in adult (92.4%) than in 1 month old (86.5%) and 5-6 day newborns (72.5%). Contrary to other species, where the sarcoplasmic reticulum Ca2+ pump is not functional in neonatal heart, it is proposed that ferret myocardium shows an early maturation of sarcoplasmic reticulum function.
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