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  • Title: Meningeal involvement in Wegener's granulomatosis confirmed and monitored by positive circulating antineutrophil cytoplasm in cerebrospinal fluid.
    Author: Spranger M, Schwab S, Meinck HM, Tischendorf M, Sis J, Breitbart A, Andrassy K.
    Journal: Neurology; 1997 Jan; 48(1):263-5. PubMed ID: 9008530.
    Abstract:
    MRI and CSF investigations revealed meningeal involvement in a 29-year-old patient with biopsy-confirmed Wegener's granulomatosis. The intracranial manifestation of Wegener's granulomatosis was supported by the detection of pathologic circulating antineutrophil cytoplasm (c-ANCA) in the CSF. We monitored disease activity by c-ANCA measurement in the CSF. After repeated cycles of intrathecal administration of methotrexate and corticoids, progression of meningeal infiltration stopped, and CSF c-ANCA titers became negative.
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