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  • Title: Proteophosphoglycan secreted by Leishmania mexicana amastigotes causes vacuole formation in macrophages.
    Author: Peters C, Stierhof YD, Ilg T.
    Journal: Infect Immun; 1997 Feb; 65(2):783-6. PubMed ID: 9009342.
    Abstract:
    The amastigote form of Leishmania mexicana parasites colonizes macrophage phagolysosomes and induces the enlargement of these compartments to form huge parasitophorous vacuoles. We report here that a purified secreted amastigote product, proteophosphoglycan, is a macromolecule which causes vacuolization of peritoneal macrophages in vitro. Secretion of this glycoconjugate by intracellular parasites may contribute to the expansion of phagolysosomal compartments in infected cells.
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