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  • Title: Scanning tunneling microscopy study of cytochrome P450 2B4 incorporated in proteoliposomes.
    Author: Uvarov VYu, Ivanov YD, Romanov AN, Gallyamov MO, Kiselyova OI, Yaminsky IV.
    Journal: Biochimie; 1996; 78(8-9):780-4. PubMed ID: 9010607.
    Abstract:
    In the present paper, the application of scanning tunneling microscopy in cytochrome P450s membrane topology is discussed. The method enables visualization of heme location in the lipid-bilayer-incorporated protein. It is supposed that the membrane-bound cytochrome P450 on the tunneling microscope substrate should behave as 'molecular diode'. A model explaining the liposome and the proteoliposome images observed is proposed.
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