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  • Title: Comparison of the antiarrhythmic activity of quinidine and quinine.
    Author: Klevans LR, Kelly RJ, Kovacs JL.
    Journal: Arch Int Pharmacodyn Ther; 1977 May; 227(1):57-68. PubMed ID: 901074.
    Abstract:
    A comparison was made between the effects of quinidine and quinine on experimental arrhythmias and on cardiac electrophysiologic parameters. Both drugs raised ventricular fibrillation thresholds, reversed aconitine-induced atrial fibrillation, decreased ouabain-induced abnormal ventricular beats, and increased atrial refractory periods and His-Purkinje conduction time. In contrast, only quinidine antagonized acetylcholine-induced atrial fibrillation. In addition, quinidine increased ventricular fibrillation thresholds and atrial refractory periods for a longer time period than quinine. These observations are discussed in terms of choosing an appropriate model for testing new compounds with suspected quinidine-like activity.
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