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  • Title: Immune response to vaccination with DNA encoding the bovine viral diarrhea virus major glycoprotein gp53 (E2).
    Author: Harpin S, Talbot B, Mbikay M, Elazhary Y.
    Journal: FEMS Microbiol Lett; 1997 Jan 15; 146(2):229-34. PubMed ID: 9011043.
    Abstract:
    Bovine viral diarrhea virus (BVDV) is a worldwide pathogen in cattle which has not been controlled by classical vaccination. The region encoding the BVDV major glycoprotein gp53 (E2) known to possess virus-neutralizing activity was cloned into a mammalian expression vector under the human cytomegalovirus (CMV) intermediate early promoter. Intramuscular and intradermal administration of the recombinant plasmid DNA into BALB/c mice induced BVDV gp53-specific antibody responses to both biotypes (cytopathic and noncytopathic) of BVDV genotype 1, and to cytopathic BVDV genotype 2. BVDV-neutralizing antibodies were generated against BVDV genotype 1 strains and they also persisted 6 months after the last injection.
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