These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Direct measurement of a tethered ligand-receptor interaction potential.
    Author: Wong JY, Kuhl TL, Israelachvili JN, Mullah N, Zalipsky S.
    Journal: Science; 1997 Feb 07; 275(5301):820-2. PubMed ID: 9012346.
    Abstract:
    Many biological recognition interactions involve ligands and receptors that are tethered rather than rigidly bound on a cell surface. A surface forces apparatus was used to directly measure the force-distance interaction between a polymer-tethered ligand and its receptor. At separations near the fully extended tether length, the ligands rapidly lock onto their binding sites, pulling the ligand and receptor together. The measured interaction potential and its dynamics can be modeled with standard theories of polymer and colloidal interactions.
    [Abstract] [Full Text] [Related] [New Search]