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  • Title: [Wound healing as an autoregulatory process].
    Author: Shekhter AB, Nikolaev AV, Berchenko GN.
    Journal: Arkh Patol; 1977; 39(5):25-32. PubMed ID: 901252.
    Abstract:
    A hypothesis of autoregulation of the reparative growth of the connective tissue based on the inverse relationship between degradation and collagen biosynthesis is suggested. At the ultrastructural level such homeostatic mechanism is realized in two stages: (1) resorption by macrophages of collagenic fibrillae of the tissue necrotized as a result of trauma and inflammation, induction of collagen genesis by cell contacts between macrophages and fibroblasts, enhanced fibrillogenesis; (2) the inhibiting effect of collagen fibers of a mature tissue contacting with fibroblasts on collagen biosynthesis with simultaneous induction of fibroclasia.
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