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  • Title: Clinical features and successful recovery from disseminated nocardiosis after BMT.
    Author: Machado CM, Macedo MC, Castelli JB, Ostronoff M, Silva AC, Zambon E, Massumoto C, Chamone DF, Dulley FL.
    Journal: Bone Marrow Transplant; 1997 Jan; 19(1):81-2. PubMed ID: 9012936.
    Abstract:
    Nocardiosis has rarely been described after BMT. When the doses of immunosuppressive therapy were tapered, a 46-year-old BMT recipient developed chronic graft-versus-host disease (GVHD) and immunosuppresive drugs were increased. Sixteen days later the patient developed nocardiosis diagnosed by lung biopsy. Trimethoprim/sulfamethoxazole (TMP/SMZ) was initiated but the doses were reduced because of rising creatinine levels. Skin and cerebral dissemination of nocardiosis was observed and TMP/SMZ doses were increased. After 4 months, the brain lesion was unaltered despite resolution of pulmonary lesions. Clinical improvement was observed after drainage of the brain abscess.
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