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  • Title: Ooplasmic round spermatid nuclear injection procedures as an experimental treatment for nonobstructive azoospermia.
    Author: Yamanaka K, Sofikitis NV, Miyagawa I, Yamamoto Y, Toda T, Antypas S, Dimitriadis D, Takenaka M, Taniguchi K, Takahashi K, Tsukamoto S, Kawamura H, Neil M.
    Journal: J Assist Reprod Genet; 1997 Jan; 14(1):55-62. PubMed ID: 9013313.
    Abstract:
    PURPOSE: Our objective was to apply ooplasmic round spermatid nuclear injections for the treatment of nonobstructive azoospermia. MATERIALS: Participants were nine azoospermic men who had previously undergone diagnostic testicular biopsy. Spermatogenetic arrest was diagnosed at the round spermatid stage (n = 6) or primary spermatocyte stage (n = 3). A second (therapeutic) testicular biopsy was performed and round spermatid nuclei were recovered from all the participants. RESULTS: Forty-nine mature oocytes were successfully injected with nuclei and then cultured for 72 hr. Twenty-four embryos were transferred to nine women. No pregnancy was achieved. CONCLUSIONS: Round spermatids can be recovered from therapeutic testicular biopsy material of men negative for round spermatids in previous routine diagnostic testicular biopsy specimens. Round spermatid nuclear injections may play a role in the treatment of nonobstructive azoospermia.
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