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  • Title: Interethnic variability in birth weight and genetic background: a study of placental alkaline phosphatase.
    Author: Amante A, Borgiani P, Gimelfarb A, Gloria-Bottini F.
    Journal: Am J Phys Anthropol; 1996 Dec; 101(4):449-53. PubMed ID: 9016360.
    Abstract:
    The relationship between human placental alkaline phosphatase (PLAP) genotype and birth weight is investigated in a sample of white, black and Puerto-Rican new-born infants from New Haven, Connecticut (total 710 subjects). Black and Puerto-Rican infants show a higher incidence of growth retardation and a higher frequency of ALPp*1/*1 genotype as compared to whites. The proportion of newborns with a low birth weight (below the 10th percentile) is lower in infants with ALPp*1/*1 genotype than in those with other PLAP genotypes, especially among non-whites. It is argued that the higher frequency of ALPp*1 allele among non-whites might be, at least in part, a consequence of their adaptation in the past to environmental conditions adverse to optimal intrauterine development.
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