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  • Title: Phosphoinositide signalling in nuclei of Friend cells: DMSO-induced differentiation reduces the association of phosphatidylinositol-transfer protein with the nucleus.
    Author: Rubbini S, Cocco L, Manzoli L, Lutterman J, Billi AM, Matteucci A, Wirtz KW.
    Journal: Biochem Biophys Res Commun; 1997 Jan 13; 230(2):302-5. PubMed ID: 9016771.
    Abstract:
    Friend erythroleukemia cells have a nuclear phosphoinositide cycle which is related to both mitogen-stimulated cell growth and erythorid differentiation. Because of the important role of the phosphatidylinositol-transfer protein (PI-TP) in phosphatidylinositol 4,5-bisphosphate (PtdInsP2) synthesis, we have analysed nuclei isolated from Friend cells for the presence of PI-TP. By Western Blotting it was demonstrated that both intact nuclei and nuclei deprived of the outer membrane contained the PI-TP alpha isoform. Upon induction of erythroid differentiation by DMSO, the amount of nuclear PI-TP alpha was greatly diminished. As shown previously, under these same conditions, nuclear phospholipase C beta1 (PLC beta1) is down-regulated as well.
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