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  • Title: Ovarian steroids in the uterine lumena. I. Effect of LH injection and mating in rabbits.
    Author: Eiler H, Bahr J, Nalbandov AV.
    Journal: Biol Reprod; 1977 Oct; 17(3):459-64. PubMed ID: 901898.
    Abstract:
    Changes in estrogen (E) and progestin (P) concentrations in the uterine lumen of rabbits following mating or injection of an ovulatory dose of luteinizing hormone (LH) were studied. There were 5 experimental groups: Group 1 (used to establish basal levels of progestin and estrogen in plasma, uterine flushing, and esophageal flushing); Group 2, injected with LH (10 mcg/kg) and killed at 1, 2, 4, 12, 24, 72, or 168 hours; Group 3, mated and killed 1, 2, or 168 hours later; Group 4, injected with 1, 10, or 100 mcg/kg of LH and killed 2 hours later; and Group 5, ovariectomized at 0 hours, injected with LH (10 mcg/kg) at 2 hours, and killed at 3 hours. In Group 1 rabbits, E was undetected in uterine or esophageal flushings while P was present in both. There was 6.3 times more P in the lumen of the uterus than in the esophagus. 1 hour after LH injection, E and P increased significantly in intact females but did not increase in ovariectomized females. While P concentration continued to decrease with time, E increased significantly at 4 hours and remained elevated in the uterine flushings. However, plasma P was significantly elevated at 1, 2, and 4 hours after LH injection, followed by a significant decrease at 12 and 24 hours and an increase at 72 and 168 hours. Plasma E elevation following LH injection was undetectable and was significantly depressed at 2-24 hours. P was the only hormone detected in the esophageal flushings. Both E and P in the uterine lumen rose 1 hour after mating, dropped in the 2nd hour, and peaked at 168 hours. 2 hours after the injection of the various doses into Group 4 animals, the P content recovered from uterine lumen increased and E was undetected. It is concluded that LH or mating induces a rapid transport of E and P into the lumen of the uterus and that the release of E and P into the lumen of the uterus requires the presence of the ovaries.
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