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  • Title: [Squamous cell carcinoma of unknown origin affecting mediastinal lymph nodes].
    Author: Yodonawa S, Mitsui K, Akaogi E, Onizuka M, Ishikawa S, Kinoshita T, Satoh Y, Mitsui T.
    Journal: Nihon Kyobu Shikkan Gakkai Zasshi; 1996 Dec; 34(12):1364-8. PubMed ID: 9022321.
    Abstract:
    A 65-year-old woman was admitted to the hospital because of an abnormal shadow on a chest X-ray film. Chest CT scans showed enlargement of the right mediastinal lymph nodes. However, no primary lesion was detected despite thorough examination. Mediastinoscopic biopsy revealed that the tumor was a lymph-node metastatic lesion of a squamous cell carcinoma of unknown origin. A thoracotomy was done and the mass was completely resected. Radiotherapy was given after the operation. We have followed the patient for 1 year since the operation, but no primary lesion has yet been detected. Metastasis of cancer of unknown origin to hilar or mediastinal lymph nodes is extremely rare, and only 6 cases have been reported previously in the Japanese medical literature.
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