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  • Title: Effect of charcoal hemoperfusion on clearance of pentamidine isethionate after accidental overdose.
    Author: Watts RG, Conte JE, Zurlinden E, Waldo FB.
    Journal: J Toxicol Clin Toxicol; 1997; 35(1):89-92. PubMed ID: 9022658.
    Abstract:
    BACKGROUND: Pentamidine isethionate is an antimicrobial agent effective in the treatment of Pneumocystis carinii pneumonia, trypanosomiasis and leishmaniasis. Severe and fatal toxicity is reported with pentamidine use. CASE REPORT: A patient received an accidental overdose (40 times the prescribed dose) of intravenous pentamidine due to a pharmacy mixing error. Charcoal hemoperfusion was utilized to attempt to lower the serum concentration of pentamidine and lessen toxicity. RESULTS: Measurement of pentamidine concentrations in the patient's blood demonstrates a beneficial effect of hemoperfusion. CONCLUSIONS: Charcoal hemoperfusion may represent a useful modality in the management of pentamidine isethionate overdosage.
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