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  • Title: Simplified radioimmunoassay of urinary drugs of abuse adsorbed on ion-exchange papers.
    Author: Alexander GJ, Machiz S.
    Journal: Clin Chem; 1977 Oct; 23(10):1921-4. PubMed ID: 902420.
    Abstract:
    A convenient screening procedure for presence of drugs of abuse in urine consists of two steps: adsorption of the drugs from urine onto a paper loaded with cation-exchange resin and detection of the adsorbed drugs by direct radioimmunoassay. The first step can be performed in the field, the second in a central laboratory. Storage and transport to the laboratory are simplified because specimens adsorbed on dried paper are stable and can be sent in letter-mail. In the laboratory, a small disc of the ion-exchange paper is exposed to antigen and antibody, rinsed, and tested for radioactivity. Discs treated with positive urines are more radioactive than discs from negative urines.
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