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  • Title: Pharmacokinetics of bendroflumethiazide.
    Author: Beermann B, Groschinsky-Grind M, Lindström B.
    Journal: Clin Pharmacol Ther; 1977 Oct; 22(4):385-8. PubMed ID: 902450.
    Abstract:
    Bendroflumethiazide (bft), 10 mg, was administered orally to 9 healthy volunteers. The concentrations of the diuretic in plasma and urine were determined by gas-liquid chromatography (GLC). Peak plasma levels (86 +/- 18 ng/ml) of bft were reached at 2 +/- 0.4 hr. The concentration declined with a mean t1/2 of 3.0 hr. The apparent volume of distribution averaged 1.48 L/kg. The major part of the drug was eliminated via nonrenal mechanisms, the nonrenal clearance being estimated to 269 +/- 77 ml/min and renal clearance to 105 +/- 24 ml/min. Urinary recovery of the thiazide averaged 30%.
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