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  • Title: BofC encodes a putative forespore regulator of the Bacillus subtilis sigma K checkpoint.
    Author: Gomez M, Cutting SM.
    Journal: Microbiology (Reading); 1997 Jan; 143 ( Pt 1)():157-170. PubMed ID: 9025289.
    Abstract:
    A mutation, bofC1, that restores sigma K activation in Bacillus subtilis strains unable to produce active sigma G has been identified. This mutation defines a new sporulation gene, bofC, that has been cloned and sequenced and encodes a 19 kDa protein. bofC is transcribed in the forespore by RNA polymerase associated with the transcription factors sigma F (E sigma F) and sigma G (E sigma G). BofC acts negatively on SpoIVB and the results described suggest that BofC regulates SpoIVB activity and its intercompartmental signalling role in the sigma K checkpoint.
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