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  • Title: [Regional suppurative lymphadenitis after BCG vaccination (author's transl)].
    Author: Brehmer W, Falkenberg N, Hussels H, Otto HS, Preussler H, Waldschmidt J.
    Journal: Dtsch Med Wochenschr; 1977 Sep 02; 102(35):1251-5. PubMed ID: 902587.
    Abstract:
    In the first half of 1975 there occurred in the Federal Republic of Germany an unusual rise in the incidence of suppurative inguinal lymphadenitis after BCG vaccination of newborns, in immediate time relation with change of the vaccine by its manufacturers, Behringwerke. The attenuated daughter strain Göteborg had been replaced by the effective but also rather aggressive strain Copenhagen 1331. The complication rate was 1.5% in West Berlin. Clinical course, operative technique as well as microbiological and histomorphological features of these cases were analyzed in a joint study. Since it is likely that, after re-admission of the Copenhagen vaccine, such complications may again occur despite reduced micro-organism count, vaccination of newborns should in future be restricted to those at risk.
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