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  • Title: [The late effects of the toxic action of platinum-containing cytostatic preparations on rat progeny].
    Author: Borovskaia TG, Smirnova ME, Filippova MV, Fomina TI, Gol'dberg VE.
    Journal: Eksp Klin Farmakol; 1996; 59(4):40-2. PubMed ID: 9026189.
    Abstract:
    Experiments on Wistar rats studied the state of the posterity born as a result of mating of intact females with males, who were injected with the antitumor drug platidiam one month before mating (once, intravenously, maximal tolerance dose). The pre- and postimplantation death rate did not grow in female rats mated with test males. However, the fetuses showed visceral anomalies and delayed development of skeleton. A decrease in the muscle tone, as well as ability for the training and extrapolation behavior, were observed in some newborn rat pups.
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