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  • Title: [The effect of cytochrome c preparations on the autoregulation of the cerebral blood flow in ischemia].
    Author: Pogorelyĭ VE, Gaevyĭ MD, Arl't AV, Davidov ER, Gatsura VV.
    Journal: Eksp Klin Farmakol; 1996; 59(5):18-20. PubMed ID: 9026201.
    Abstract:
    The effect of animal cytochrome C (Ca), biotechnological cytochrome (Cb) and its hemtetradecapeptide (HTDP) on cerebral blood flow autoregulation during rapid decrease of systemic arterial pressure (SAP) was studied in acute experiments on rats. Cytochrome C preparations caused no effect on the autoregulatory responses of the cerebral vessels in animals with normal cerebral circulation. Injection of 5 mg/kg Ca and Cb and 0.8 mg/kg HTDP promoted restoration of the phenomenon of cerebral blood flow autoregulation in ischemic brain damage in change of SAP from 120 to 60 mm Hg. Prophylactic injection of 20 mg/kg Ca and Cb and 3.3 mg/kg HTDP prevented cerebral blood flow autoregulation disturbance caused by transitory brain ischemia.
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