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  • Title: [Serotonin in diabetic retinopathy].
    Author: Andrzejewska-Buczko J, Pawlak D, Walkowiak M, Stankiewicz A.
    Journal: Klin Oczna; 1996 Feb; 98(2):101-4. PubMed ID: 9026563.
    Abstract:
    PURPOSE: The present study was designed to evaluate a possible participation of serotonin in the development of retinopathy in diabetes mellitus. MATERIAL AND METHODS: Serotonin of whole blood and platelets was studied in 12 patients with Type I and II diabetes using high pressure liquid chromatography method. RESULTS: The concentration of serotonin in the blood was markedly increased (210 +/- 50 ng/ml in diabetes and 150 +/- 35 ng/ml in control, p < 0.01) and not changed in platelets in diabetes. There was a relation between blood serotonin level and the presence of retinopathy. CONCLUSION: These results suggest that serotonin may be involved in the pathogenesis of diabetic microangiopathy.
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